![]() ![]() This shift in chloride ions results in hyperpolarization and stabilization of the cellular plasma membrane. It enhances the inhibitory effects of GABA, which increases the conductance of chloride ions in the cell. Lorazepam binds to benzodiazepine receptors on the postsynaptic GABA-A ligand-gated chloride channel neuron at several sites within the central nervous system (CNS). Chemotherapy-associated anticipatory nausea and vomiting (adjunct or breakthrough).Rapid tranquilization of the agitated patient.Anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia.Short-term (4 months) relief of anxiety symptoms related to anxiety disorders.Lorazepam is also one of the few sedative-hypnotics with a relatively clean side effect profile. Lorazepam has common use as the sedative and anxiolytic of choice in the inpatient setting owing to its fast (1 to 3 minutes) onset of action when administered intravenously. It went on the market in the United States in 1977. Lorazepam is a benzodiazepine medication developed by DJ Richards. Review interprofessional team strategies for improving care coordination and communication to properly use lorazepam to improve patient outcomes in the varied scenarios where lorazepam is effective.Describe the adverse events of lorazepam.Summarize the various indications for initiating therapy with lorazepam.Identify the mechanism of action of lorazepam. ![]() It also highlights the interprofessional team's role in managing lorazepam therapy. ![]() This activity covers lorazepam, including mechanism of action, pharmacology, adverse event profiles, eligible patient populations, and monitoring. Off-label (non-FDA-approved) uses for lorazepam include rapid tranquilization of the agitated patient, alcohol withdrawal delirium, alcohol withdrawal syndrome, insomnia, panic disorder, delirium, chemotherapy-associated anticipatory nausea, and vomiting (adjunct or breakthrough), as well as psychogenic catatonia. Lorazepam is FDA-approved for short-term (4 months) relief of anxiety symptoms related to anxiety disorders, anxiety-associated insomnia, anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia, and treatment of status epilepticus. ![]()
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